Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 13/20 | 0.41 |
| ▸ | RAB9A | P51151 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | CASP1 | P29466 | 4/20 | 0.37 |
| ▸ | CASP7 | P55210 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12912280 | 0.81 | ENPP3 (0.42) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL17469574 | 0.75 | KDM4E (0.48) | KDM4EKMT2AMEN1AKT1AKT2 | |
| SCHEMBL25311041 | 0.74 | PDE4A (0.42) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12911395 | 0.73 | KDM4E (0.47) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL23748001 | 0.72 | KDM4E (0.46) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL25310755 | 0.72 | NPC1 (0.38) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL23456462 | 0.71 | USP2 (0.38) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL17515540 | 0.69 | KDM4E (0.43) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL13304403 | 0.69 | KDM4E (0.40) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL12910698 | 0.68 | MEN1 (0.46) | KDM4EKMT2AMEN1TSHRPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250101041-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250101041-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM2 | KDM4E 1876/4885KMT2A 960/4885MEN1 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.