Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.32 |
| ▸ | CDK1 | P06493 | 4/20 | 0.32 |
| ▸ | PRKACA | P17612 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.32 |
| ▸ | GSK3A | P49840 | 4/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.32 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314883 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL314881 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL314882 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10098578 | 0.88 | AKT1 (0.42) | AKT1SMN1; SMN2 | |
| SCHEMBL316012 | 0.86 | TNIK (0.35) | — | |
| SCHEMBL314273 | 0.85 | TP53 (0.40) | BCHEALDH1A1HPGDESR2 | |
| SCHEMBL314274 | 0.85 | TP53 (0.40) | BCHEALDH1A1HPGDESR2 | |
| SCHEMBL314275 | 0.85 | TP53 (0.40) | BCHEALDH1A1HPGDESR2 | |
| SCHEMBL314780 | 0.85 | ESR2 (0.35) | ALDH1A1HPGDESR2HSD17B10LMNA | |
| SCHEMBL315176 | 0.84 | AKT1 (0.37) | AKT1ALDH1A1HPGDESR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | claimed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | claimed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| WO-2007079820-A1 | TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306042-A1 | Triazole Derivatives | TGFBR1, TGFBR2, SMAD3 | CDC7 658/4885MAPK10 1454/4885MAPK9 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.