Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.51 |
| ▸ | CA9 | Q16790 | 5/20 | 0.51 |
| ▸ | CA12 | O43570 | 4/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598333 | 0.83 | CA1 (0.50) | CA1CA9HSD11B1CA2MEN1 | |
| SCHEMBL13933202 | 0.79 | CA1 (0.49) | CA1CA9HSD11B1CA2MEN1 | |
| SCHEMBL4056753 | 0.79 | CA1 (0.51) | CA1CA9HSD11B1CA2DRD2 | |
| SCHEMBL7438888 | 0.79 | PREP (0.43) | CA1CA9CA12HSD11B1CA2 | |
| SCHEMBL7943234 | 0.79 | HSD11B1 (0.39) | CA1CA9CA12HSD11B1CA2 | |
| SCHEMBL18159331 | 0.79 | HSD11B1 (0.47) | CA1CA9HSD11B1CA2MEN1 | |
| SCHEMBL1179389 | 0.79 | L3MBTL1 (0.51) | CA1CA9HSD11B1CA2MEN1 | |
| SCHEMBL30064871 | 0.78 | HSD11B1 (0.39) | CA1CA9CA12HSD11B1CA2 | |
| SCHEMBL19616849 | 0.78 | HSD11B1 (0.39) | CA1CA9CA12HSD11B1CA2 | |
| SCHEMBL1882570 | 0.77 | CA12 (0.61) | CA1CA9CA12PREPL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081825-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO LTD (JP) | 2010-04-01 | — | — | US | disclosed |
| EP-2098509-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | Taisho Pharmaceutical Co. Ltd. (JP) | 2009-09-09 | — | — | EP | disclosed |
| EP-0579731-A1 | DISUBSTITUTED NAPHTHALENES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-01-26 | — | — | EP | disclosed |
| EP-0579731-A4 | DISUBSTITUTED NAPHTHALENES. | SMITHKLINE BEECHAM CORP (US) | 1993-12-07 | — | — | EP | disclosed |
| WO-1992017172-A1 | DISUBSTITUTED NAPHTHALENES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081825-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | MCHR1, MCHR2, MC5R | CA1 4180/4885CA9 4234/4885CA12 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.