Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5550742 | 0.97 | ALDH1A1 (0.57) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Bicarbonate SCHEMBL28647212 | 0.97 | ALDH1A1 (0.57) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Bicarbonate SCHEMBL8169227 | 0.97 | ALDH1A1 (0.57) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Tetrahydrofuran SCHEMBL1950354 | 0.93 | — | — | |
| Tetrahydrofuran SCHEMBL16166505 | 0.93 | ALDH1A1 (0.61) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Tetrahydrofuran SCHEMBL905739 | 0.93 | ALDH1A1 (0.61) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Tetrahydrofuran SCHEMBL3294902 | 0.93 | ALDH1A1 (0.61) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Tetrahydrofuran SCHEMBL11210398 | 0.90 | ALDH1A1 (0.57) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Oxalic Acid SCHEMBL29396445 | 0.87 | ALDH1A1 (0.53) | ALDH1A1GLAKMT2AMEN1TP53 | |
| Tetrahydrofuran SCHEMBL8590475 | 0.87 | ALDH1A1 (0.53) | ALDH1A1GLAKMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046489-B1 | IMPROVED MONOPERSULFATE TREATMENT OF MEMBRANES | SIEMENS INDUSTRY INC (US) | 2012-08-29 | — | — | EP | disclosed |
| CN-101511456-B | Improved Monopersulfate Membrane Treatment | SIEMENS INDUSTRY INC | 2012-06-13 | — | — | CN | disclosed |
| US-20100000942-A1 | MONOPERSULFATE TREATMENT OF MEMBRANES | SIEMENS WATER TECHNOLOGIES LLC | 2010-01-07 | — | — | US | disclosed |
| CN-101511456-A | Improved Monopersulfate Membrane Treatment | SIEMENS WATER TECH CORP (US) | 2009-08-19 | — | — | CN | disclosed |
| EP-2046489-A1 | IMPROVED MONOPERSULFATE TREATMENT OF MEMBRANES | Siemens Water Technologies Corp. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008006173-A1 | IMPROVED MONOPERSULFATE TREATMENT OF MEMBRANES | SIEMENS WATER TECHNOLOGIES CORP. (US) | 2008-01-17 | — | — | WO | disclosed |