Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL16166505 | 1.00 | ALDH1A1 (0.61) | ALDH1A1CA1CA9GLACA2 | |
| Tetrahydrofuran SCHEMBL905739 | 1.00 | ALDH1A1 (0.61) | ALDH1A1CA1CA9GLACA2 | |
| Tetrahydrofuran SCHEMBL1950354 | 1.00 | — | — | |
| Tetrahydrofuran SCHEMBL11210398 | 0.96 | ALDH1A1 (0.57) | ALDH1A1CA1CA9GLACA2 | |
| Bicarbonate SCHEMBL28647212 | 0.96 | ALDH1A1 (0.57) | ALDH1A1CA1CA9GLACA2 | |
| Bicarbonate SCHEMBL5550742 | 0.96 | ALDH1A1 (0.57) | ALDH1A1CA1CA9GLACA2 | |
| Bicarbonate SCHEMBL8169227 | 0.96 | ALDH1A1 (0.57) | ALDH1A1CA1CA9GLACA2 | |
| Bicarbonate SCHEMBL3145335 | 0.93 | ALDH1A1 (0.53) | ALDH1A1CA1CA9GLACA2 | |
| Tetrahydrofuran SCHEMBL8590475 | 0.93 | ALDH1A1 (0.53) | ALDH1A1CA1CA9GLACA2 | |
| Oxalic Acid SCHEMBL30284941 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CA1CA9GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111278357-B | Synthetic film composition comprising polyurethane and polyoxazoline | 帝斯曼知识产权资产管理有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-115697254-A | Medical implant for cartilage replacement and method for producing such an implant | 帝斯曼知识产权资产管理有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-111278358-B | Synthetic membrane compositions comprising fluorinated polyurethanes | 帝斯曼知识产权资产管理有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-113518634-B | Radiopaque medical assemblies and devices | 帝斯曼知识产权资产管理有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-113518634-A | Radiopaque medical assemblies and devices | 帝斯曼知识产权资产管理有限公司 | 2021-10-19 | — | — | CN | disclosed |
| CN-111278358-A | Synthetic membrane compositions comprising fluorinated polyurethanes | 帝斯曼知识产权资产管理有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-111278357-A | Synthetic membrane compositions comprising polyurethane and polyoxazoline | 帝斯曼知识产权资产管理有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-106928247-A | Spiral shell oxindole compounds and its purposes as therapeutic agent | 泽农医药公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| EP-2069303-B1 | ANTIVIRAL PROTEASE INHIBITORS | GILEAD SCIENCES INC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-7723380-B2 | Tetrahydrofuro[2,3-b]furyl carbamates containing an (oxy)hydrazide group; these compounds target the HIV protease in both wild type and mutant strains of HIV. | GILEAD SCIENCES, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090306112-A1 | ANTIVIRAL PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| EP-2069303-A2 | ANTIVIRAL PROTEASE INHIBITORS | Gilead Sciences, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20090105279-A1 | Antiviral protease inhibitors | GILEAD SCIENCES, INC. | 2009-04-23 | — | — | US | disclosed |
| WO-2008011117-A2 | ANTIVIRAL PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| CN-1333580-A | Non-aqueous electrochemistry device | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2002-01-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105279-A1 | Antiviral protease inhibitors | ACE, TMPRSS15, MME | ALDH1A1 3629/4885CA1 1565/4885CA9 1115/4885 |
| US-20090306112-A1 | ANTIVIRAL PROTEASE INHIBITORS | ACE, DNPEP, TMPRSS15 | ALDH1A1 3653/4885CA1 1590/4885CA9 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.