Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30725889 | 0.88 | MAOB (0.52) | RETCYP19A1MAOB | |
| SCHEMBL29566683 | 0.77 | RET (0.45) | RET | |
| SCHEMBL30175370 | 0.77 | CDK2 (0.36) | RETKDM4EALDH1A1GAAHPGD | |
| SCHEMBL25252185 | 0.77 | CDK2 (0.36) | RETKDM4EALDH1A1 | |
| SCHEMBL31044666 | 0.76 | RET (0.46) | RETCYP19A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL28993707 | 0.76 | RET (0.44) | RET | |
| SCHEMBL30175294 | 0.75 | RET (0.43) | RETKDM4EALDH1A1HPGDHTT | |
| SCHEMBL30175296 | 0.75 | RET (0.45) | RET | |
| SCHEMBL30175349 | 0.75 | CYP11B1 (0.41) | RETCYP11B1CYP11B2 | |
| SCHEMBL30175335 | 0.75 | RET (0.37) | RETKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163437-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2025-03-04 | — | — | CN | disclosed |