Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039202 | 0.90 | ALDH1A1 (0.62) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL7755246 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL15256939 | 0.87 | ALDH1A1 (0.59) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL31337846 | 0.87 | ALDH1A1 (0.59) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL4661575 | 0.85 | ALDH1A1 (0.57) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL4688815 | 0.85 | KMT2A (0.60) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL14369823 | 0.84 | ALDH1A1 (0.56) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL1532433 | 0.84 | KMT2A (0.73) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL27288913 | 0.84 | ALDH1A1 (0.56) | ALDH1A1LMNAKMT2AMAPTTSHR | |
| SCHEMBL27859868 | 0.84 | ALDH1A1 (0.56) | ALDH1A1LMNAKMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197879-B1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS INC (US) | 2014-01-22 | — | — | EP | claimed |
| EP-2197879-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-06-23 | — | — | EP | claimed |
| US-7687496-B2 | C7-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | claimed |
| WO-2009051580-A1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | claimed |
| US-20090099224-A1 | C7- substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099224-A1 | C7- substituted camptothecin analogs | ABCB1, ABCC1, ABCG2 | ALDH1A1 979/4885LMNA 1725/4885KMT2A 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.