SCHEMBL31468420

SCHEMBL31468420

O=C(O)c1ccc(-c2nc(-c3ccc(Cl)cc3F)c3sccn23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43
EIF4E P06730 2/20 0.40
SRD5A2 P31213 1/20 0.39
KMO O15229 2/20 0.39
RORC P51449 5/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
PPARG P37231 1/20 0.37
MAP2K4 P45985 1/20 0.37
CDH1 P12830 1/20 0.36
APC P25054 1/20 0.36
CTNNB1 P35222 1/20 0.36
TCF7L2 Q9NQB0 1/20 0.36
ADH5 P11766 1/20 0.36
FASN P49327 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31468387 0.88 TNK2 (0.38) KDM4ENPC1RAB9AEIF4ERORC
SCHEMBL31468428 0.85 TNK2 (0.41) KDM4ENPC1RAB9ASMN1; SMN2RORC
SCHEMBL31468298 0.83 TTR (0.39) KDM4ENPC1RAB9ASMN1; SMN2EIF4E
SCHEMBL31468385 0.82 KDM4E (0.41) KDM4ENPC1RAB9ASMN1; SMN2CRHBP
SCHEMBL31468303 0.82 NR1I3 (0.39) KMT2A
SCHEMBL31468320 0.81 KDM4E (0.42) KDM4ENPC1RAB9ASMN1; SMN2KMO
SCHEMBL31468395 0.81 KDM4E (0.50) KDM4ENPC1RAB9ASMN1; SMN2RORC
SCHEMBL31468401 0.79 KMO (0.41) KDM4ENPC1RAB9ASMN1; SMN2CRHBP
SCHEMBL31468419 0.79 NR1I3 (0.38) KDM4ENPC1RAB9ASMN1; SMN2CRHBP
SCHEMBL31468429 0.77 RARA (0.48) KDM4ENPC1RAB9ASMN1; SMN2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025064210-A1 INHIBITORS OF BILIVERDIN REDUCTASE B (BLVRB) BLOOD CELL TECHNOLOGIES, LLC (US) 2025-03-27 WO disclosed