Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15972966 | 0.88 | ROCK2 (0.59) | AAK1ROCK2 | |
| SCHEMBL31468763 | 0.81 | ROCK2 (0.50) | AAK1ROCK2ROCK1 | |
| SCHEMBL19946104 | 0.81 | ROCK2 (0.56) | AAK1ROCK2 | |
| SCHEMBL18901287 | 0.81 | AAK1 (0.53) | AAK1ROCK2ROCK1 | |
| SCHEMBL31474211 | 0.80 | AAK1 (0.49) | AAK1ROCK2ROCK1 | |
| SCHEMBL31474174 | 0.79 | AAK1 (0.43) | AAK1ROCK2LMNAMAPTROCK1 | |
| SCHEMBL11558683 | 0.78 | ROCK2 (0.49) | AAK1ROCK2ROCK1 | |
| SCHEMBL16345579 | 0.77 | ROCK2 (0.69) | ROCK2ROCK1 | |
| SCHEMBL31468772 | 0.76 | ROCK2 (0.55) | AAK1ROCK2LMNAMAPTROCK1 | |
| SCHEMBL9671869 | 0.75 | LMNA (0.56) | AAK1ROCK2LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025060978-A1 | TRICYCLIC PYRIDINE COMPOUND ACTING AS SARM1 ENZYME ACTIVITY INHIBITOR, AND USE THEREOF | 科辉智药(深圳)新药研究中心有限公司 | 2025-03-27 | — | — | WO | disclosed |
| CN-119661547-A | Tricyclic pyridine compounds as SARM1 enzyme activity inhibitors and application thereof | 科辉智药(深圳)新药研究中心有限公司 | 2025-03-21 | — | — | CN | disclosed |