SCHEMBL31469743

SCHEMBL31469743

OC1([C@@H](CC(F)(F)F)c2ccc(Cl)cn2)CCNCC1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.39
SLC6A2 P23975 13/20 0.37
SLC6A4 P31645 9/20 0.37
TRPA1 O75762 1/20 0.36
SLC6A3 Q01959 6/20 0.32
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31469806 0.83 SLC6A2 (0.39) DRD2SLC6A2SLC6A4SLC6A3
SCHEMBL31469747 0.81 DRD2 (0.39) DRD2SLC6A2SLC6A4TRPA1PDK2
SCHEMBL31469731 0.81 DRD2 (0.39) DRD2SLC6A2SLC6A4TRPA1PDK2
SCHEMBL31282925 0.76 DRD2 (0.41) DRD2SLC6A2SLC6A4
SCHEMBL31469759 0.76 DRD2 (0.41) DRD2SLC6A2SLC6A4
SCHEMBL25389094 0.76 DRD2 (0.41) DRD2SLC6A2SLC6A4
SCHEMBL25389095 0.76 DRD2 (0.41) DRD2SLC6A2SLC6A4
SCHEMBL31469749 0.76 DRD2 (0.41) DRD2SLC6A2SLC6A4
SCHEMBL31469774 0.73 DRD2 (0.39) DRD2SLC6A2SLC6A4TRPA1SLC6A3
SCHEMBL31469756 0.73 DRD2 (0.39) DRD2SLC6A2SLC6A4TRPA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025030002-A2 DGK TARGETING COMPOUNDS AND USES THEREOF ARVINAS OPERATIONS, INC. (US) 2025-02-06 WO disclosed