Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731930 | 0.98 | ALDH1A1 (0.34) | ALDH1A1HPGDHTTGAAPOLB | |
| SCHEMBL17338875 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL31056967 | 0.89 | MEN1 (0.35) | ALDH1A1HPGDHTTKDM4E | |
| SCHEMBL18375146 | 0.79 | — | — | |
| Methane SCHEMBL15741155 | 0.77 | — | — | |
| SCHEMBL8381891 | 0.74 | CES2 (0.33) | ALDH1A1TSHR | |
| SCHEMBL18043532 | 0.71 | — | — | |
| SCHEMBL8381270 | 0.71 | KDM4E (0.31) | POLBKDM4EL3MBTL1 | |
| SCHEMBL11098876 | 0.68 | CNR2 (0.40) | ALDH1A1HTTGAAPOLBL3MBTL1 | |
| SCHEMBL31655370 | 0.67 | ACE (0.39) | ALDH1A1HTTGAAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12281101-B2 | Bicyclic lactams and methods of use thereof | GENENTECH, INC. (US) | 2025-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281101-B2 | Bicyclic lactams and methods of use thereof | LSS, LPXN, CYP1B1 | ALDH1A1 1195/4885HPGD 2167/4885TSHR 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.