SCHEMBL3147462

SCHEMBL3147462

Nc1c(F)c(F)c(Oc2cc(F)c(F)c(F)c2F)c(F)c1F

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
POLB P06746 1/20 0.35
HSP90AA1 P07900 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2194521 0.89 MAPT (0.40) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL3143336 0.79 MAPT (0.39) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL4900526 0.78 AKR1B1 (0.34)
SCHEMBL31131009 0.78 AKR1B1 (0.34)
SCHEMBL8151983 0.77 KDM4E (0.34) MAPTKDM4ECRHBPCRHR2
SCHEMBL8143722 0.75 MAPT (0.36) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL8919707 0.75 CA1 (0.40)
SCHEMBL9140608 0.74 TRPV4 (0.33) MAPTKDM4ECRHBPCRHR2
SCHEMBL8152772 0.73 KDM4E (0.34) MAPTKDM4ECRHBPCRHR2
SCHEMBL5613149 0.73 MEN1 (0.35) MAPTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117203264-A Polyimide precursor composition and polyimide 杰富意化学株式会社 2023-12-08 CN disclosed
CN-107531999-B Thermally conductive silicone grease composition 信越化学工业株式会社 2020-10-27 CN disclosed
EP-1782881-B1 Membrane and associated method GEN ELECTRIC (US) 2010-02-10 EP disclosed
EP-1782881-A1 Membrane and associated method General Electric Company (US) 2007-05-09 EP disclosed
US-5449741-A Electronics with impact strength NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1995-09-12 US disclosed