Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.56 |
| ▸ | WNT1 | P04628 | 7/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | CLK3 | P49761 | 1/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 5/20 | 0.47 |
| ▸ | CDK8 | P49336 | 5/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25602112 | 0.94 | DYRK1A (0.62) | DYRK1AWNT1CLK2CLK3PRKCZ | |
| SCHEMBL31501389 | 0.94 | DYRK1A (0.62) | DYRK1AWNT1CLK2CLK3PRKCZ | |
| SCHEMBL30964876 | 0.81 | ABL1 (0.52) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL30210556 | 0.77 | MAPT (0.48) | DYRK1AWNT1CLK2CLK3MAPT | |
| SCHEMBL19643731 | 0.76 | DYRK1A (0.47) | DYRK1AWNT1CLK2CLK3MAPT | |
| SCHEMBL30878058 | 0.76 | DYRK1A (0.47) | DYRK1AWNT1CLK2CLK3MAPT | |
| SCHEMBL31071772 | 0.75 | PIK3CD (0.48) | DYRK1AWNT1GSK3BABL1CCNC | |
| SCHEMBL25424298 | 0.75 | ABL1 (0.56) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL359835 | 0.75 | DYRK1A (0.53) | DYRK1AWNT1CLK2MAPTGSK3B | |
| SCHEMBL29650645 | 0.75 | PRKCZ (0.75) | DYRK1ACLK2PRKCZMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084074-A1 | SUBSTITUTED HETEROCYCLES AS HSET INHIBITORS | MERCK PATENT GMBH (DE) | 2025-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250084074-A1 | SUBSTITUTED HETEROCYCLES AS HSET INHIBITORS | VHL, CDKN1A, CCNI | DYRK1A 3206/4885WNT1 970/4885CLK2 2049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.