Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.42 |
| ▸ | TNKS | O95271 | 4/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | TACR3 | P29371 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ERG | P11308 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 3/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | C1S | P09871 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314041 | 0.91 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| SCHEMBL314043 | 0.91 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| SCHEMBL314042 | 0.91 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL314380 | 0.84 | GPR6 (0.33) | TNKS2TACR3GPR6TACR2TACR1 | |
| Trifluoroacetic Acid SCHEMBL314381 | 0.84 | GPR6 (0.33) | TNKS2TACR3GPR6TACR2TACR1 | |
| SCHEMBL314133 | 0.83 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| SCHEMBL314713 | 0.83 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| SCHEMBL314365 | 0.83 | TNKS2 (0.40) | TNKS2TNKSP2RX7TACR3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL314137 | 0.82 | ALDH1A1 (0.42) | P2RX7GPR6 | |
| Trifluoroacetic Acid SCHEMBL314138 | 0.82 | ALDH1A1 (0.42) | P2RX7GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966211-B1 | TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | claimed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | claimed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| EP-1966211-B1 | TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306042-A1 | Triazole Derivatives | TGFBR1, TGFBR2, SMAD3 | TNKS2 630/4885TNKS 534/4885P2RX7 3204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.