SCHEMBL31479524

SCHEMBL31479524

Cc1ncc2c(-c3ccc(F)cc3C(=O)N(CC(F)F)C(C)C)cc(C3CCN(C(=O)OC(C)(C)C)CC3)cn12

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.39
GPR119 Q8TDV5 1/20 0.39
TP53 P04637 4/20 0.39
POLB P06746 1/20 0.38
WNT3A P56704 1/20 0.38
ENPP2 Q13822 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31479587 0.96 GPR119 (0.39) SMN1; SMN2GPR119TP53POLB
SCHEMBL31479192 0.96 GPR119 (0.39) SMN1; SMN2GPR119TP53POLB
SCHEMBL31478913 0.93 GPBAR1 (0.39) SMN1; SMN2GPR119POLB
SCHEMBL31479100 0.90 GPR119 (0.39) SMN1; SMN2GPR119TP53POLBENPP2
SCHEMBL31479700 0.89 RET (0.37) SMN1; SMN2GPR119WNT3AENPP2
SCHEMBL31479243 0.88 GPR119 (0.40) SMN1; SMN2GPR119TP53POLB
SCHEMBL31479899 0.87 ALOX5AP (0.37) SMN1; SMN2GPR119TP53POLB
SCHEMBL31479892 0.86 GPBAR1 (0.38) SMN1; SMN2GPR119POLB
SCHEMBL31479471 0.86 SLC6A2 (0.33) TP53
SCHEMBL31479476 0.84 HCRTR1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067111-A1 MENIN-MLL INTERACTION INHIBITOR AND PREPARATION METHOD THEREFOR, AND APPLICATION 苏州必扬医药科技有限公司 2025-04-03 WO disclosed