SCHEMBL31483002

SCHEMBL31483002

COc1ncc(-c2ccn3nc(NC(=O)NCCOc4ccccc4)cc3n2)cc1NS(C)(=O)=O

nearest known ligand 0.79

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 18/20 0.79
PIK3CA P42336 15/20 0.79
PIK3CD O00329 12/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483058 0.76 PIK3CD (0.71) PIK3CGPIK3CAPIK3CD
SCHEMBL31483080 0.75 PIK3CG (0.72) PIK3CGPIK3CAPIK3CD
SCHEMBL31483090 0.74 PIK3CG (0.73) PIK3CGPIK3CAPIK3CD
SCHEMBL31483007 0.73 PIK3CA (0.88) PIK3CGPIK3CAPIK3CD
SCHEMBL31483165 0.73 PIK3CG (0.69) PIK3CGPIK3CAPIK3CD
SCHEMBL31483034 0.68 PIK3CG (1.00) PIK3CGPIK3CAPIK3CD
SCHEMBL31483072 0.67 PIK3CG (1.00) PIK3CGPIK3CAPIK3CD
SCHEMBL31483064 0.67 PIK3CG (1.00) PIK3CGPIK3CAPIK3CD
SCHEMBL31483028 0.66 PIK3CG (1.00) PIK3CGPIK3CAPIK3CD
SCHEMBL12664700 0.64 PIK3CA (0.62) PIK3CGPIK3CAPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed