SCHEMBL31483058

SCHEMBL31483058

COc1ncc(-c2ccn3nc(N)cc3n2)cc1NS(C)(=O)=O

nearest known ligand 0.71

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 16/20 0.71
PIK3CA P42336 11/20 0.67
PIK3CG P48736 11/20 0.67
PIK3CB P42338 3/20 0.49
PI4KA P42356 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483081 0.81 PIK3CD (0.70) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL31483093 0.80 PIK3CG (1.00) PIK3CDPIK3CAPIK3CG
SCHEMBL31483002 0.76 PIK3CG (0.79) PIK3CDPIK3CAPIK3CG
SCHEMBL15959838 0.72 PIK3CD (0.61) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL15959803 0.72 PIK3CD (0.60) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483017 0.71 PIK3CD (0.56) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL116324 0.69 PIK3CA (0.56) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL15951721 0.69 PIK3CD (0.72) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL29139465 0.68 PIK3CA (0.62) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL30609840 0.68 PIK3CA (0.62) PIK3CDPIK3CAPIK3CGPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed