SCHEMBL31483017

SCHEMBL31483017

COc1ncc(-c2ccn3nc(N)cc3c2)cc1NS(=O)(=O)C1CC1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 11/20 0.56
PIK3CA P42336 10/20 0.55
MTOR P42345 2/20 0.49
ATM Q13315 1/20 0.49
ATR Q13535 1/20 0.49
PIK3CG P48736 4/20 0.47
PIK3CB P42338 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483081 0.89 PIK3CD (0.70) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL15952414 0.77 PIK3CD (0.52) PIK3CDPIK3CAMTORATMATR
SCHEMBL15959761 0.77 PIK3CD (0.52) PIK3CDPIK3CAMTORATMATR
SCHEMBL31483001 0.76 PIK3CG (0.63) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483065 0.74 PIK3CD (0.53) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL15959837 0.74 PIK3CD (0.49) PIK3CDPIK3CAMTORATMATR
SCHEMBL15959843 0.73 PIK3CD (0.48) PIK3CDPIK3CAMTORATMATR
SCHEMBL19996332 0.73 PIK3CA (0.55) PIK3CDPIK3CAMTORATMATR
SCHEMBL15674002 0.73 PIK3CD (0.53) PIK3CDPIK3CAMTORATMATR
SCHEMBL31483117 0.72 PIK3CD (0.51) PIK3CDPIK3CAPIK3CGPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed