SCHEMBL31483081

SCHEMBL31483081

COc1ncc(-c2ccn3nc(N)cc3c2)cc1NS(C)(=O)=O

nearest known ligand 0.70

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 13/20 0.70
PIK3CA P42336 8/20 0.56
PIK3CG P48736 7/20 0.56
PIK3CB P42338 4/20 0.53
PI4KA P42356 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483017 0.89 PIK3CD (0.56) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483058 0.81 PIK3CD (0.71) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL31483001 0.79 PIK3CG (0.63) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483065 0.78 PIK3CD (0.53) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483117 0.76 PIK3CD (0.51) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483046 0.74 PIK3CD (0.53) PIK3CDPIK3CAPIK3CGPIK3CB
SCHEMBL31483029 0.72 PIK3CA (0.52) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL116324 0.71 PIK3CA (0.56) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA
SCHEMBL17022099 0.68 PIK3CA (1.00) PIK3CA
SCHEMBL3762546 0.68 PIK3CD (0.69) PIK3CDPIK3CAPIK3CGPIK3CBPI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed