SCHEMBL31483065

SCHEMBL31483065

COc1ncc(-c2ccn3nc(N)cc3c2)cc1F

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 14/20 0.53
PIK3CG P48736 13/20 0.53
PIK3CA P42336 10/20 0.53
PTGES2 Q9H7Z7 1/20 0.39
MAPT P10636 1/20 0.39
CASP1 P29466 1/20 0.39
PIK3CB P42338 1/20 0.39
GRM2 Q14416 1/20 0.39
AURKA O14965 1/20 0.38
TTK P33981 1/20 0.38
AURKB Q96GD4 1/20 0.38
INCENP Q9NQS7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483001 0.91 PIK3CG (0.63) PIK3CDPIK3CGPIK3CAPIK3CB
SCHEMBL31483046 0.85 PIK3CD (0.53) PIK3CDPIK3CGPIK3CAPIK3CB
SCHEMBL31483117 0.84 PIK3CD (0.51) PIK3CDPIK3CGPIK3CAMAPTCASP1
SCHEMBL31483081 0.78 PIK3CD (0.70) PIK3CDPIK3CGPIK3CAPIK3CB
SCHEMBL31483029 0.78 PIK3CA (0.52) PIK3CDPIK3CGPIK3CAPIK3CB
SCHEMBL31483017 0.74 PIK3CD (0.56) PIK3CDPIK3CGPIK3CAPIK3CB
SCHEMBL26906271 0.72 PIK3CD (0.36) PIK3CDPIK3CGPIK3CA
SCHEMBL26906242 0.69 PIK3CD (0.34) PIK3CDPIK3CGPIK3CA
SCHEMBL31483093 0.69 PIK3CG (1.00) PIK3CDPIK3CGPIK3CA
SCHEMBL22129467 0.69 NOS3 (0.43) PIK3CDPIK3CGPIK3CAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed