SCHEMBL3148484

SCHEMBL3148484

COCOc1cccc(C(=O)O)c1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.66
NR4A2 P43354 9/20 0.61
MRGPRX4 Q96LA9 2/20 0.57
AKR1C3 P42330 1/20 0.56
NR4A1 P22736 2/20 0.55
NR4A3 Q92570 2/20 0.55
RAB9A P51151 2/20 0.54
NPC1 O15118 1/20 0.54
NR1H4 Q96RI1 2/20 0.54
PLA2G4B P0C869 1/20 0.52
TP53 P04637 1/20 0.51
PKM P14618 1/20 0.51
NFKB1 P19838 1/20 0.51
NFKB2 Q00653 1/20 0.51
RELA Q04206 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30442255 0.86 MAOB (0.62) KMT2ARAB9ANPC1SMN1; SMN2
SCHEMBL3151885 0.86 MAOB (0.62) KMT2ARAB9ANPC1SMN1; SMN2
SCHEMBL2868546 0.86 KMT2A (0.61) KMT2ANR4A2MRGPRX4AKR1C3NR4A1
SCHEMBL6356224 0.85 KMT2A (0.47) KMT2ANR4A2MRGPRX4RAB9ANPC1
SCHEMBL3069825 0.85 MRGPRX4 (0.56) KMT2AMRGPRX4RAB9ANPC1TP53
SCHEMBL28124115 0.85 PARP1 (0.67) KMT2A
SCHEMBL1665041 0.85 KMT2A (0.73) KMT2ANR4A2MRGPRX4AKR1C3NR4A1
SCHEMBL30517635 0.85 KMT2A (0.73) KMT2ANR4A2MRGPRX4AKR1C3NR4A1
SCHEMBL9368628 0.84 ESR1 (0.52) KMT2ANR4A2PKMSMN1; SMN2
SCHEMBL7516815 0.83 KMT2A (0.48) KMT2AMRGPRX4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4631952-A1 GLUCOCORTICOID RECEPTOR AGONIST AND CONJUGATE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2025-10-15 EP disclosed
WO-2024149093-A1 GLUCOCORTICOID RECEPTOR AGONIST AND CONJUGATE THEREOF 四川科伦博泰生物医药股份有限公司 2024-07-18 WO disclosed
CN-105593339-A Polymerizable liquid crystal compound, and liquid crystal composition and optical film comprising same LG CHEMICAL LTD 2016-05-18 CN disclosed
EP-1751113-B1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS BRISTOL MYERS SQUIBB CO (US) 2010-03-10 EP disclosed
US-7674828-B2 Urea antagonists of P2Y1receptor useful in the treatment of thrombotic conditions BRISTOL-MYERS SQUIBB COMPANY (US) 2010-03-09 US disclosed
US-20080280905-A1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS BRISTOL MYERS SQUIBB COMPANY (US) 2008-11-13 US disclosed
US-7388021-B2 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions BRISTOL MYERS SQUIBB COMPANY (US) 2008-06-17 US disclosed
EP-1751113-A1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS Bristol-Myers Squibb Pharma Company (US) 2007-02-14 EP disclosed
WO-2005113511-A9 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS BRISTOL MYERS SQUIBB CO (US) 2006-02-02 WO disclosed
WO-2005113511-A1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-12-01 WO disclosed
US-20050267119-A1 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions BRISTOL-MYERS SQUIBB COMPANY 2005-12-01 US disclosed
US-20020099073-A1 Modulators of protein tyrosine phosphatases (PTPases) NOVO NORDISK A/S (DK) 2002-07-25 US disclosed
WO-2002004458-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) NOVO NORDISK A/S (DK) 2002-01-17 WO disclosed
US-5380854-A Anticoagulants for surgery BRISTOL-MYERS SQUIBB COMPANY (US) 1995-01-10 US disclosed
EP-0600084-A1 INDOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-06-08 EP disclosed
US-5254576-A Diphenyl-heterocyclic-oxazole as platelet aggregation inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1993-10-19 US disclosed
WO-1993003012-A1 INDOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-02-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080280905-A1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS P2RY1, P2RY11, P2RY2 KMT2A 4568/4885NR4A2 1531/4885MRGPRX4 255/4885
US-20050267119-A1 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions P2RY1, P2RY11, P2RY2 KMT2A 4568/4885NR4A2 1531/4885MRGPRX4 255/4885
US-20020099073-A1 Modulators of protein tyrosine phosphatases (PTPases) PTPN1, PTPRO, PTPRS KMT2A 3426/4885NR4A2 1624/4885MRGPRX4 1589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.