Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL31148452 | 0.96 | HTT (0.51) | HTTMAPTROCK2ROCK1POLB | |
| SCHEMBL31148427 | 0.93 | HTT (0.47) | HTTMAPTPOLBPTPN11CTNNB1 | |
| SCHEMBL30423043 | 0.93 | HTT (0.47) | HTTMAPTPOLBPTPN11CTNNB1 | |
| SCHEMBL31485476 | 0.92 | HTT (0.46) | HTTMAPTROCK2POLBPTPN11 | |
| SCHEMBL31485466 | 0.92 | HTT (0.46) | HTTMAPTROCK2POLBPTPN11 | |
| Hydrochloric Acid SCHEMBL30422837 | 0.92 | HTT (0.47) | HTTMAPTPOLBPTPN11CTNNB1 | |
| Hydrochloric Acid SCHEMBL25421188 | 0.92 | HTT (0.45) | HTTMAPTROCK2POLBPTPN11 | |
| Hydrochloric Acid SCHEMBL30421555 | 0.92 | HTT (0.45) | HTTMAPTROCK2POLBPTPN11 | |
| Hydrochloric Acid SCHEMBL25421178 | 0.92 | HTT (0.45) | HTTMAPTROCK2POLBPTPN11 | |
| Trifluoroacetic Acid SCHEMBL31485480 | 0.88 | HTT (0.43) | HTTMAPTPOLBPTPN11CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122192-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. | 2025-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122192-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RTCB, NSUN2, PRPF19 | HTT 3559/4885MAPT 4668/4885ROCK2 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.