Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | MASP2 | O00187 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148682 | 1.00 | KLKB1 (0.42) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3154010 | 0.92 | KLKB1 (0.41) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL1432500 | 0.92 | KLKB1 (0.41) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3147613 | 0.92 | KLKB1 (0.41) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3140131 | 0.91 | KLKB1 (0.42) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3140100 | 0.91 | KLKB1 (0.42) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3140160 | 0.90 | KLKB1 (0.43) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3140132 | 0.90 | KLKB1 (0.43) | KLKB1NAMPTMASP2PDPK1PSMB1 | |
| SCHEMBL3148485 | 0.89 | NAMPT (0.47) | KLKB1NAMPTMASP2PSMB5FURIN | |
| SCHEMBL3148503 | 0.89 | NAMPT (0.47) | KLKB1NAMPTMASP2PSMB5FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100076015-A1 | Aminopyridine Derivatives | VANTIA LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076015-A1 | Aminopyridine Derivatives | CHRM1, ARG1, ARG2 | KLKB1 3491/4885NAMPT 1657/4885MASP2 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.