Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | DRD2 | P14416 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SOD1 | P00441 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559845 | 0.90 | DRD2 (0.73) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL11447131 | 0.89 | DRD2 (0.71) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| SCHEMBL18937451 | 0.86 | DRD2 (0.82) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| SCHEMBL16303868 | 0.84 | DRD2 (0.79) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| SCHEMBL11354876 | 0.84 | HSD17B10 (1.00) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| SCHEMBL10994325 | 0.84 | HSD17B10 (0.73) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL11209809 | 0.84 | DRD2 (0.79) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL11639840 | 0.84 | HSD17B10 (0.73) | HSD17B10DRD2MEN1KMT2AHTR2A | |
| SCHEMBL11404382 | 0.84 | KCNH2 (0.81) | DRD2HTR2ADRD4HTR1AHTR7 | |
| SCHEMBL3186225 | 0.83 | HSD17B10 (0.91) | HSD17B10DRD2MEN1KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247420-B2 | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents | REVIVA PHARMACEUTICALS, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| EP-2162135-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING QUINOLINONE BASED ATYPICAL ANTIPSYCHOTIC AGENTS | Reviva Pharmaceuticals, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008144764-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING QUINOLINONE BASED ATYPICAL ANTIPSYCHOTIC AGENTS | REVIVA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080293736-A1 | Compositions, Synthesis, and Methods of Using Quinolinone Based Atypical Antipsychotic Agents | REVIVA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |
| US-4250310-A | ANTIARRHYTHMIA AND VASODILATION AGENTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1981-02-10 | — | — | US | disclosed |
| US-4140790-A | ANTIARRHYTHMIA, CORONARY DILATORS | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1979-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293736-A1 | Compositions, Synthesis, and Methods of Using Quinolinone Based Atypical Antipsychotic Agents | GRIN2D, GRIN2C, AP3D1 | HSD17B10 1029/4885DRD2 26/4885MEN1 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.