SCHEMBL31489403

SCHEMBL31489403

Nc1nc2cc(-c3nccc(-c4cnn(C(c5ccc(F)cc5)C5CC(F)(F)C5)c4)n3)ccn2n1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 6/20 0.33
CSNK1D P48730 2/20 0.32
CSNK1E P49674 2/20 0.32
RIPK1 Q13546 1/20 0.32
PIK3CD O00329 4/20 0.31
MAPK14 Q16539 1/20 0.30
PIK3CA P42336 2/20 0.30
IRAK1 P51617 1/20 0.30
IRAK4 Q9NWZ3 1/20 0.30
MKNK1 Q9BUB5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489333 0.87 PIK3CG (0.33) PIK3CGCSNK1DCSNK1ERIPK1PIK3CD
SCHEMBL31489902 0.85 PIK3CG (0.36) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489567 0.85 PIK3CG (0.33) PIK3CGRIPK1PIK3CDPIK3CAMKNK1
SCHEMBL31489445 0.83 PIK3CG (0.35) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489307 0.82 PIK3CG (0.34) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489345 0.82 PIK3CG (0.34) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489895 0.81 PIK3CG (0.36) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489918 0.81 PIK3CG (0.33) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489669 0.81 PIK3CG (0.35) PIK3CGRIPK1PIK3CDMAPK14PIK3CA
SCHEMBL31489599 0.80 PIK3CG (0.38) PIK3CGRIPK1PIK3CDMAPK14PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed