SCHEMBL31489445

SCHEMBL31489445

CC(F)C(c1ccc(F)cc1)n1cc(-c2ccnc(-c3ccn4nc(N)nc4c3)n2)cn1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 9/20 0.35
PIK3CD O00329 8/20 0.35
PIK3CA P42336 3/20 0.35
RIPK1 Q13546 3/20 0.35
MAPK14 Q16539 1/20 0.34
MKNK1 Q9BUB5 1/20 0.32
HSP90AA1 P07900 1/20 0.32
ROCK2 O75116 1/20 0.32
PAK4 O96013 1/20 0.32
JAK1 P23458 1/20 0.32
PIK3CB P42338 1/20 0.32
CSNK1A1 P48729 1/20 0.32
AAK1 Q2M2I8 1/20 0.32
PIP4K2C Q8TBX8 1/20 0.32
CSNK1G1 Q9HCP0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489902 0.90 PIK3CG (0.36) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489895 0.87 PIK3CG (0.36) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489860 0.87 PIK3CD (0.32) PIK3CGPIK3CDPIK3CARIPK1MKNK1
SCHEMBL31489669 0.86 PIK3CG (0.35) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489918 0.86 PIK3CG (0.33) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489599 0.85 PIK3CG (0.38) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489345 0.85 PIK3CG (0.34) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489307 0.85 PIK3CG (0.34) PIK3CGPIK3CDPIK3CARIPK1MAPK14
SCHEMBL31489134 0.84 MEN1 (0.34) PIK3CGPIK3CDPIK3CARIPK1MKNK1
SCHEMBL31489441 0.82 RIPK1 (0.40) PIK3CGPIK3CDPIK3CARIPK1PAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed