SCHEMBL31489758

SCHEMBL31489758

Cc1nn(C(c2ccc(F)cc2)C(C)(F)F)cc1-c1cncc(Cl)n1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489387 0.81 POLB (0.32) POLBMAPTNPC1RAB9A
SCHEMBL31489393 0.81 POLB (0.32) POLBMAPTNPC1RAB9A
SCHEMBL31489553 0.80 CYP11B2 (0.40) CYP11B1CYP11B2
SCHEMBL31489816 0.80 CYP11B2 (0.40) CYP11B1CYP11B2
SCHEMBL31489830 0.78
SCHEMBL31489355 0.78
SCHEMBL31489943 0.78 PIK3CG (0.36)
SCHEMBL31489251 0.78 PIK3CG (0.39) CYP11B1CYP11B2NPC1RAB9A
SCHEMBL31489619 0.78 PIK3CG (0.36)
SCHEMBL31489944 0.72 NPC1 (0.32) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed