Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3153055 | 0.99 | HRH1 (0.38) | HRH1HRH2HRH3CACNA1GGRIA1 | |
| SCHEMBL2334157 | 0.86 | MEN1 (0.35) | HTR1ADRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL3144491 | 0.85 | KDM4E (0.37) | HTR1ADRD2HTR2ADRD3HTR2C | |
| Hydrochloric Acid SCHEMBL3156540 | 0.84 | HTR1A (0.49) | HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL3149372 | 0.84 | PIK3CD (0.48) | CACNA1GHTR1ADRD2HTR2ADRD4 | |
| Hydrochloric Acid SCHEMBL3152996 | 0.84 | HRH3 (0.43) | HRH3DRD2DRD3DRD4 | |
| SCHEMBL2336011 | 0.84 | CARM1 (0.43) | HRH1HRH2HRH3CACNA1GGRIA1 | |
| SCHEMBL2335598 | 0.83 | MAP4K1 (0.37) | HTR1ADRD2HTR2ADRD3DRD4 | |
| Hydrochloric Acid SCHEMBL3153060 | 0.83 | CARM1 (0.43) | HRH1HRH2HRH3CACNA1GGRIA1 | |
| Hydrochloric Acid SCHEMBL3149246 | 0.82 | MAP4K1 (0.36) | HTR1ADRD2HTR2ADRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | HTR7, HTR1A, HTR2C | HRH1 24/4885HRH2 23/4885HRH3 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.