Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 12/20 | 0.39 |
| ▸ | ACACA | Q13085 | 8/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797081 | 0.82 | CKS1B (0.37) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL3154917 | 0.82 | ACACB (0.38) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL3149200 | 0.82 | ACACB (0.38) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL3149216 | 0.78 | CKS1B (0.40) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL1712060 | 0.74 | MTNR1A (0.40) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL1711953 | 0.73 | MTNR1A (0.39) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL1711943 | 0.72 | MTNR1A (0.42) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL1712486 | 0.72 | MTNR1A (0.39) | HTR2CMTNR1AMTNR1B | |
| SCHEMBL3753033 | 0.72 | PDCD1 (0.36) | HTR2CMTNR1AMTNR1BDRD2 | |
| SCHEMBL1267140 | 0.72 | KCNH2 (0.43) | CKS1BSKP1SKP2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954697-B1 | PERI CONDENSED TRICYCLIC COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2010-02-24 | — | — | EP | disclosed |