Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.32 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12225261 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL11647740 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| Hydrochloric Acid SCHEMBL27921673 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| Hydrochloric Acid SCHEMBL10482154 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| Hydrochloric Acid SCHEMBL6912638 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL5857102 | 0.76 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL2868169 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL30503396 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL21549468 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CA2POLBTYR | |
| SCHEMBL21500784 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CA2POLBTYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103073902-A | Polymer-modified asphalt and preparation method thereof | CHINA NAT OFFSHORE OIL CORP | 2013-05-01 | — | — | CN | claimed |
| CN-1158311-C | Process for hydrogenating a conjugated diene polymer | ������ѧ��ʽ���� | 2004-07-21 | — | — | CN | claimed |
| CN-1314919-A | method for hydrogenating conjugated diene polymer | KOREA KUMHO PHTROCHEMICAL CO L (KR) | 2001-09-26 | — | — | CN | claimed |
| CN-108137748-B | Process for preparing polyolefins having one or more pendant functional groups | SABIC环球技术有限责任公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-108368270-B | Process for preparing a polyolefin-based graft copolymer comprising a first functionalized short chain branched polyolefin block and one or more polymer side chains | SABIC环球技术有限责任公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-108291032-B | Process for preparing a polyolefin graft copolymer comprising a first long-chain branched polyolefin block and one or more polymer side chains | SABIC环球技术有限责任公司 | 2021-01-26 | — | — | CN | disclosed |
| CN-107223138-B | Process for preparing polyolefins having one or more end-functionalized branches | SABIC环球技术有限责任公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-107531829-B | Process for preparing a block copolymer comprising a first polyolefin block and a second polymer block and product obtained from said process | SABIC环球技术有限责任公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-103073902-B | Polymer-modified asphalt and preparation method thereof | CHINA NAT OFFSHORE OIL CORP | 2015-01-28 | — | — | CN | disclosed |
| CN-103073902-A | Polymer-modified asphalt and preparation method thereof | CHINA NAT OFFSHORE OIL CORP | 2013-05-01 | — | — | CN | disclosed |
| EP-1435362-B1 | Process for polymer hydrogenation using lithium hydride prepared from reactor equipped with high-speed injection nozzle | KOREA KUMHO PETROCHEM CO LTD (KR) | 2010-03-03 | — | — | EP | disclosed |
| CN-101407564-A | Process for the preparation of a hydrogenated conjugated diene-based polymer | KOREA KUMHO PETROCHEM CO LTD (KR) | 2009-04-15 | — | — | CN | disclosed |
| US-6864326-B2 | Process for polymer hydrogenation using lithium hydride prepared from reactor equipped with high-speed injection nozzle | KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) | 2005-03-08 | — | — | US | disclosed |
| CN-1158311-C | Process for hydrogenating a conjugated diene polymer | ������ѧ��ʽ���� | 2004-07-21 | — | — | CN | disclosed |
| EP-1435362-A1 | Process for polymer hydrogenation using lithium hydride prepared from reactor equipped with high-speed injection nozzle | Korea Kumho Petrochemical Co. Ltd. (KR) | 2004-07-07 | — | — | EP | disclosed |
| CN-1314919-A | method for hydrogenating conjugated diene polymer | KOREA KUMHO PHTROCHEMICAL CO L (KR) | 2001-09-26 | — | — | CN | disclosed |