Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4250873 | 0.84 | HCRTR2 (0.47) | NPC1KMT2AHCRTR2GPR183ALDH1A1 | |
| Fumaric Acid SCHEMBL4250868 | 0.84 | HCRTR2 (0.47) | NPC1KMT2AHCRTR2GPR183ALDH1A1 | |
| SCHEMBL3149555 | 0.82 | KMT2A (0.48) | NPC1KMT2AGPR183ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4243020 | 0.81 | KMT2A (0.47) | NPC1KMT2AGPR183ALDH1A1KDM4E | |
| SCHEMBL3155256 | 0.77 | KMT2A (0.47) | NPC1KMT2AGPR183ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4243022 | 0.76 | KMT2A (0.47) | NPC1KMT2AGPR183ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4254355 | 0.75 | CHRM2 (0.50) | NPC1KMT2AHCRTR2GPR183ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4244565 | 0.74 | CHRM2 (0.49) | NPC1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3154099 | 0.74 | HCN4 (0.47) | NPC1KMT2AHCRTR2GPR183ALDH1A1 | |
| SCHEMBL3153236 | 0.74 | CHRM2 (0.48) | NPC1KMT2AALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076325-B2 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-12-13 | — | — | US | disclosed |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | OXER1, NR1H3, OXSR1 | NPC1 498/4885KMT2A 1570/4885HCRTR2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.