SCHEMBL31497183

SCHEMBL31497183

O=C(O)c1cc(Cl)ccc1OCC(F)F

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.60
TSHR P16473 2/20 0.60
ALDH1A1 P00352 2/20 0.47
TP53 P04637 1/20 0.47
MRGPRX4 Q96LA9 6/20 0.47
LCLAT1 Q6UWP7 2/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
PTGER1 P34995 1/20 0.46
HTR2A P28223 2/20 0.45
HTR2C P28335 2/20 0.45
HTR2B P41595 2/20 0.45
TDP1 Q9NUW8 1/20 0.44
POLB P06746 1/20 0.43
HPGD P15428 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CASP1 P29466 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.42
MYC P01106 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20522092 1.00 GAA (0.60) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL20522192 0.83 PKM (0.46) GAATSHRALDH1A1MRGPRX4LCLAT1
SCHEMBL20521955 0.82 TSHR (0.65) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL31497167 0.82 TSHR (0.65) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL16448844 0.81 ABCB1 (0.48) GAATSHRMRGPRX4LCLAT1PTGDR2
SCHEMBL1505175 0.81 GAA (0.56) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL1505174 0.81 GAA (0.56) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL31497228 0.79 GAA (0.61) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL987385 0.79 GAA (0.61) GAATSHRALDH1A1TP53MRGPRX4
SCHEMBL29488334 0.79 TSHR (0.53) GAATSHRALDH1A1TP53MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120136858-A Compounds useful as ALCAT1 inhibitors 中美博瑞纳制药有限公司 2025-06-13 CN disclosed
CN-110709394-B Compounds useful as ALCAT1 inhibitors 中美博瑞纳制药有限公司 2025-02-21 CN disclosed