Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31497228 | 1.00 | GAA (0.61) | GAATSHRALDH1A1TP53RAB9A | |
| SCHEMBL13951308 | 0.89 | TSHR (0.63) | GAATSHRALDH1A1TP53RAB9A | |
| SCHEMBL12781084 | 0.87 | GAA (0.61) | GAATSHRALDH1A1TP53RAB9A | |
| SCHEMBL31497167 | 0.87 | TSHR (0.65) | GAATSHRALDH1A1TP53MRGPRX4 | |
| SCHEMBL20521955 | 0.87 | TSHR (0.65) | GAATSHRALDH1A1TP53MRGPRX4 | |
| Hydrochloric Acid SCHEMBL1505021 | 0.86 | GAA (0.60) | GAATSHRALDH1A1TP53RAB9A | |
| SCHEMBL929689 | 0.85 | TSHR (0.63) | GAATSHRALDH1A1TP53RAB9A | |
| Hydrochloric Acid SCHEMBL1505162 | 0.84 | GAA (0.58) | GAATSHRALDH1A1TP53RAB9A | |
| SCHEMBL20522075 | 0.84 | GAA (0.61) | GAATSHRALDH1A1TP53MRGPRX4 | |
| SCHEMBL1153890 | 0.83 | GAA (0.60) | GAATSHRALDH1A1MRGPRX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630541-B2 | Compounds useful as inhibitors of ALCAT 1 | PERENNA PHARMACEUTICALS, INC. (US) | 2026-05-19 | — | — | US | disclosed |
| US-20220089582-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | PERENNA PHARMACEUTICALS, INC. | 2022-03-24 | — | — | US | disclosed |
| US-11208404-B2 | Compounds useful as inhibitors of ALCAT 1 | PERENNA PHARMACEUTICALS, INC. (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200109136-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | PERENNA PHARMACEUTICALS, INC. | 2020-04-09 | — | — | US | disclosed |
| EP-3601274-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | Perenna Pharmaceuticals, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| CN-110709394-A | Compounds useful as ALCAT1 inhibitors | 中美博瑞纳制药有限公司 | 2020-01-17 | — | — | CN | disclosed |
| WO-2018178304-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | PERENNA PHARMACEUTICALS, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
| US-8835475-B2 | Compounds as cannabinoid receptor ligands | ABBVIE INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8501794-B2 | Compounds as cannabinoid receptor ligands | ABBVIE INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2344463-A2 | 1,2 -THIAZOL YL DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20110082116-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2011-04-07 | — | — | US | disclosed |
| US-7872033-B2 | N-[(5Z)-4-butyl-2-tert-butylisothiazol-5(2H)-ylidene]-5-chloro-2-methoxybenzamide; CB2 receptors ligand; antiinflammatory, analgesic agent; autoimmune diseases; neuroprotectants | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |
| US-20100234345-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| WO-2010054024-A2 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2010-05-14 | — | — | WO | disclosed |
| EP-2146973-A2 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-01-27 | — | — | EP | disclosed |
| US-20090023789-A1 | N-[(5Z)-4-butyl-2-tert-butylisothiazol-5(2H)-ylidene]-5-chloro-2-methoxybenzamide; CB2 receptors ligand; antiinflammatory, analgesic agent; autoimmune diseases; neuroprotectants | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2008130953-A2 | 2-IMIN0IS0THIAZ0LE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023789-A1 | N-[(5Z)-4-butyl-2-tert-butylisothiazol-5(2H)-ylidene]-5-chloro-2-methoxybenzamide; CB2 receptors ligand; antiinflammatory, analgesic agent; autoimmune diseases; neuroprotectants | CNR2, CNR1, TBXA2R | GAA 4851/4885TSHR 192/4885ALDH1A1 1737/4885 |
| US-20220089582-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | ACAT1, ACAT2, SLC33A1 | GAA 53/4885TSHR 3322/4885ALDH1A1 65/4885 |
| US-12630541-B2 | Compounds useful as inhibitors of ALCAT 1 | LCLAT1, LPCAT1, ACAT2 | GAA 263/4885TSHR 3727/4885ALDH1A1 511/4885 |
| US-11208404-B2 | Compounds useful as inhibitors of ALCAT 1 | ACAT1, ACAT2, SLC33A1 | GAA 53/4885TSHR 3322/4885ALDH1A1 65/4885 |
| US-20110082116-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | CNR1, CNR2, GPR18 | GAA 4657/4885TSHR 292/4885ALDH1A1 1465/4885 |
| US-20100234345-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | CNR1, CNR2, GPR18 | GAA 4687/4885TSHR 285/4885ALDH1A1 1518/4885 |
| US-20200109136-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1 | ACAT1, ACAT2, SLC33A1 | GAA 53/4885TSHR 3322/4885ALDH1A1 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.