Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HRH2 | P25021 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145421 | 0.86 | DPP4 (0.48) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL3149403 | 0.86 | MAPK1 (0.62) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL3144506 | 0.80 | AVPR1A (0.47) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL3149378 | 0.80 | TMEM97 (0.47) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL3154241 | 0.80 | TMEM97 (0.47) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL3149722 | 0.78 | SCN5A (0.49) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL23055438 | 0.77 | MEN1 (0.55) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL92518 | 0.77 | L3MBTL1 (0.56) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL5778191 | 0.76 | MEN1 (0.53) | TMEM97SIGMAR1HTR1AHRH2HRH1 | |
| SCHEMBL4979370 | 0.73 | MEN1 (0.46) | HTR1AHTR2CPTGDR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687620-B2 | [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | WYETH LLC (US) | 2010-03-30 | — | — | US | disclosed |
| EP-1497293-B1 | (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH CORP (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070004707-A1 | [1,4]Diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | RAMAMOORTHY P S | 2007-01-04 | — | — | US | disclosed |
| US-7129237-B2 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1497293-A1 | (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH | 2004-01-15 | — | — | US | disclosed |
| WO-2003091250-A1 | [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004707-A1 | [1,4]Diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | TMEM97 248/4885SIGMAR1 122/4885HTR1A 2/4885 |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | TMEM97 205/4885SIGMAR1 123/4885HTR1A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.