Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146674 | 0.92 | CHRNB4 (0.43) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3151015 | 0.91 | FFAR4 (0.40) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3147012 | 0.90 | FFAR4 (0.44) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3256998 | 0.90 | FFAR4 (0.42) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3147063 | 0.89 | P2RX7 (0.44) | P2RX7FFAR4ABL1CHRNB4CHRNA3 | |
| SCHEMBL3147051 | 0.88 | FFAR4 (0.38) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3151249 | 0.86 | FFAR4 (0.38) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3151266 | 0.86 | FFAR4 (0.38) | P2RX7FFAR4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3145499 | 0.85 | ALDH1A1 (0.39) | P2RX7FFAR4ABL1 | |
| SCHEMBL3151357 | 0.84 | ABL1 (0.42) | FFAR4ABL1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |