Venglustat

SCHEMBL31522597

CC(C)(NC(=O)O[C@H]1CN2CCC1CC2)c1csc(-c2ccc(F)cc2)n1.O=C(O)C[C@H](O)C(=O)O

nearest known ligand 0.83

Known targets — ChEMBL curated mechanism

The experimentally established mechanism targets of Venglustat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	UGCG known ✓	Q16739	1/20	0.83

▸	NTMT1	Q9BV86	20/20	0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Venglustat SCHEMBL29358474	1.00	NTMT1 (0.83)	NTMT1UGCG
Venglustat SCHEMBL12615333	0.91	NTMT1 (1.00)	NTMT1UGCG
Venglustat SCHEMBL29359568	0.91	NTMT1 (1.00)	NTMT1UGCG
Venglustat SCHEMBL12615329	0.91	NTMT1 (1.00)	NTMT1UGCG
Venglustat SCHEMBL19844439	0.91	NTMT1 (1.00)	NTMT1UGCG
SCHEMBL19407265	0.84	NTMT1 (1.00)	NTMT1UGCG
SCHEMBL18309554	0.83	NTMT1 (1.00)	NTMT1UGCG
Malic Acid SCHEMBL23234120	0.81	NTMT1 (0.50)	NTMT1UGCG
Malic Acid SCHEMBL17504472	0.80	NTMT1 (0.52)	NTMT1UGCG
Malic Acid SCHEMBL17504470	0.80	NTMT1 (0.52)	NTMT1UGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4559918-A2	GLUCOSYLCERAMIDE SYNTHASE INHIBITORS	Genzyme Corporation (US)	2025-05-28	—	—	EP	disclosed
EP-3673906-B1	GLUCOSYLCERAMIDE SYNTHASE INHIBITORS	GENZYME CORP (US)	2025-05-14	—	—	EP	disclosed