SCHEMBL31526268

SCHEMBL31526268

Cc1ncnc(-c2ccccc2)c1CSC[C@H]1O[C@@H](n2cc(C#Cc3cncnc3)c3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ DOT1L Q8TEK3 5/20 0.47
▸ PRMT5 O14744 2/20 0.47
▸ PRMT3 O60678 2/20 0.47
▸ DNMT1 P26358 2/20 0.47
▸ EHMT2 Q96KQ7 1/20 0.47
▸ RNMT O43148 1/20 0.45
▸ ADK P55263 2/20 0.44
▸ NAE1 Q13564 3/20 0.43
▸ UBA3 Q8TBC4 2/20 0.43
▸ CA2 P00918 1/20 0.43
▸ UBA1 P22314 1/20 0.43
▸ SAE1 Q9UBE0 1/20 0.43
▸ UBA2 Q9UBT2 1/20 0.43
▸ NNMT P40261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526284 0.89 DOT1L (0.46) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526137 0.89 DOT1L (0.46) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526295 0.87 DOT1L (0.47) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526158 0.85 ADK (0.58) DOT1LPRMT5PRMT3DNMT1ADK
SCHEMBL31526324 0.84 DOT1L (0.47) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526091 0.84 DOT1L (0.45) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526327 0.83 DOT1L (0.45) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526205 0.83 RNMT (0.48) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31526352 0.82 ADK (0.53) DOT1LPRMT5PRMT3DNMT1EHMT2
SCHEMBL31570702 0.82 DOT1L (0.43) DOT1LPRMT5PRMT3DNMT1EHMT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
EP-4553080-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2025-05-14 — — EP disclosed
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