SCHEMBL31526294

SCHEMBL31526294

Cc1noc(-c2ccccc2)c1CSC[C@H]1O[C@@H](n2cc(C#Cc3ccccn3)c3c(N)ncnc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 2/20 0.34
▸ PRMT9 Q6P2P2 1/20 0.34
▸ NAE1 Q13564 3/20 0.34
▸ CA2 P00918 3/20 0.34
▸ UBA3 Q8TBC4 2/20 0.34
▸ UBA1 P22314 1/20 0.34
▸ SAE1 Q9UBE0 1/20 0.34
▸ UBA2 Q9UBT2 1/20 0.34
▸ DOT1L Q8TEK3 3/20 0.33
▸ PRMT3 O60678 1/20 0.33
▸ DNMT1 P26358 1/20 0.33
▸ EHMT2 Q96KQ7 1/20 0.33
▸ RNMT O43148 1/20 0.33
▸ ADK P55263 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31570715 1.00 PRMT5 (0.34) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526261 0.91 RNMT (0.35) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526188 0.90 NAE1 (0.33) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526105 0.90 RNMT (0.34) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526345 0.90 DOT1L (0.35) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526174 0.90 RNMT (0.35) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526233 0.90 DOT1L (0.43) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526300 0.90 RNMT (0.35) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526376 0.90 NAE1 (0.34) PRMT5PRMT9NAE1CA2UBA3
SCHEMBL31526181 0.86 ADK (0.41) PRMT5PRMT9DOT1LPRMT3DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
Send feedback