Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152915 | 1.00 | SLC6A2 (0.55) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL3155280 | 0.99 | SLC6A2 (0.54) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL3155288 | 0.99 | SLC6A2 (0.54) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| SCHEMBL3144780 | 0.90 | SCN9A (0.45) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| SCHEMBL3144773 | 0.90 | SCN9A (0.45) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| SCHEMBL27709339 | 0.90 | SCN9A (0.45) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| SCHEMBL3144752 | 0.89 | MKNK1 (0.46) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| SCHEMBL3144764 | 0.89 | MKNK1 (0.46) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL3158719 | 0.89 | SLC6A4 (0.45) | SLC6A2CHRM3MKNK1SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL3158725 | 0.89 | SLC6A4 (0.45) | SLC6A2CHRM3MKNK1SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828182-B1 | THERAPEUTIC PYRAZOLO[3,4-B]PYRIDINES AND INDAZOLES | WARNER LAMBERT CO (US) | 2010-03-10 | — | — | EP | claimed |
| US-20080293715-A1 | Therapeutic Pyrazolo[3,4-b]Pyridines and Indazoles | WARNER LAMBERT COMPANY LLC (US) | 2008-11-27 | — | — | US | claimed |
| US-20060116376-A1 | Therapeutic pyrazolo[3,4-B]pyridines and indazoles | WARNER-LAMBERT COMPANY LLC | 2006-06-01 | — | — | US | claimed |
| EP-1828182-B1 | THERAPEUTIC PYRAZOLO[3,4-B]PYRIDINES AND INDAZOLES | WARNER LAMBERT CO (US) | 2010-03-10 | — | — | EP | disclosed |
| US-7485636-B2 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | PFIZER INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080293715-A1 | Therapeutic Pyrazolo[3,4-b]Pyridines and Indazoles | WARNER LAMBERT COMPANY LLC (US) | 2008-11-27 | — | — | US | disclosed |
| US-7423054-B2 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | WARNER LAMBERT COMPANY LLC (US) | 2008-09-09 | — | — | US | disclosed |
| US-20060217376-A1 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | WARNER-LAMBERT COMPANY LLC | 2006-09-28 | — | — | US | disclosed |
| US-20060116376-A1 | Therapeutic pyrazolo[3,4-B]pyridines and indazoles | WARNER-LAMBERT COMPANY LLC | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293715-A1 | Therapeutic Pyrazolo[3,4-b]Pyridines and Indazoles | P2RX3, P2RX4, ACHE | SLC6A2 355/4885CHRM3 84/4885MKNK1 4067/4885 |
| US-20060116376-A1 | Therapeutic pyrazolo[3,4-B]pyridines and indazoles | P2RX3, P2RX4, ACHE | SLC6A2 355/4885CHRM3 84/4885MKNK1 4067/4885 |
| US-20060217376-A1 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | P2RX3, P2RX4, ACHE | SLC6A2 355/4885CHRM3 84/4885MKNK1 4067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.