Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR1 | P15328 | 15/20 | 0.54 |
| ▸ | FOLR2 | P14207 | 11/20 | 0.54 |
| ▸ | GART | P22102 | 13/20 | 0.54 |
| ▸ | SLC46A1 | Q96NT5 | 11/20 | 0.54 |
| ▸ | SLC19A1 | P41440 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165332 | 0.96 | FOLR1 (0.55) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3159856 | 0.95 | FOLR1 (0.55) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL1604542 | 0.88 | FOLR1 (0.55) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL1604409 | 0.87 | FOLR1 (0.54) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3153296 | 0.86 | FOLR1 (0.58) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL1604470 | 0.86 | FOLR1 (0.54) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL1604629 | 0.86 | FOLR1 (0.57) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL1605557 | 0.85 | FOLR1 (0.53) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3159171 | 0.85 | GART (0.72) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3159155 | 0.85 | GART (0.72) | FOLR1FOLR2GARTSLC46A1SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | disclosed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | disclosed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | disclosed |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-12-06 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | disclosed |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | WAYNE STATE UNIVERSITY | 2017-04-27 | — | — | US | disclosed |
| US-9511069-B2 | Selective proton coupled folate transporter and folate receptor, and GRAFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-12-06 | — | — | US | disclosed |
| EP-2995199-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2995199-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2348843-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2015-11-11 | — | — | EP | disclosed |
| EP-2348843-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2015-11-11 | — | — | EP | disclosed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLR1 3/4885FOLR2 4/4885GART 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.