SCHEMBL31542282

SCHEMBL31542282

COc1cc(N2CCOc3ccc(C#N)cc32)c2cc(C)c(=O)n(C)c2c1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ BRPF1 P55201 6/20 0.37
▸ BRD1 O95696 3/20 0.37
▸ BRPF3 Q9ULD4 3/20 0.37
▸ BRD4 O60885 2/20 0.37
▸ BRD9 Q9H8M2 2/20 0.37
▸ SCN9A Q15858 5/20 0.37
▸ TRIM24 O15164 1/20 0.37
▸ BRD7 Q9NPI1 1/20 0.37
▸ SCN5A Q14524 2/20 0.36
▸ PIK3CA P42336 6/20 0.35
▸ PIK3CD O00329 6/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29471259 0.83 BRPF1 (0.39) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL26548588 0.83 BRPF1 (0.39) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL24316561 0.82 BRPF1 (0.40) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL24316845 0.73 FGFR1 (0.42) PIK3CAPIK3CD
SCHEMBL24317223 0.71 RXFP1 (0.38) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL24317133 0.71 CLK1 (0.36) BRPF1
SCHEMBL31542345 0.71 BRPF1 (0.35) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL29471157 0.71 RXFP1 (0.38) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL26547528 0.70 RXFP1 (0.36) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL31542279 0.69 BRPF1 (0.35) BRPF1BRD1BRPF3BRD4BRD9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025062330-A1 HETEROCYCLIC COMPOUNDS AS CBP SELECTIVE DEGRADERS AURIGENE ONCOLOGY LIMITED (IN) 2025-03-27 — — WO disclosed
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