SCHEMBL31542345

SCHEMBL31542345

Cc1cc2c(N3CCN(C)c4ccc(C#N)cc43)cc(OS(=O)(=O)C(F)(F)F)cc2n(C)c1=O

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BRPF1 P55201 9/20 0.35
▸ BRD1 O95696 6/20 0.35
▸ BRPF3 Q9ULD4 6/20 0.35
▸ BRD4 O60885 4/20 0.35
▸ BRD9 Q9H8M2 4/20 0.35
▸ BRD7 Q9NPI1 2/20 0.35
▸ TRIM24 O15164 1/20 0.35
▸ RXFP1 Q9HBX9 1/20 0.32
▸ CASP3 P42574 1/20 0.30
▸ AKR1C3 P42330 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29471259 0.86 BRPF1 (0.39) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL26548588 0.86 BRPF1 (0.39) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL24317223 0.82 RXFP1 (0.38) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL29471157 0.82 RXFP1 (0.38) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL31542279 0.80 BRPF1 (0.35) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL29471262 0.79 MAPT (0.37) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL26548555 0.79 MAPT (0.37) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL31542294 0.76 DRD2 (0.37) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL31542290 0.75 KDM1A (0.33) BRPF1BRD1BRPF3BRD4BRD9
SCHEMBL31542340 0.75 TP53 (0.34) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025062330-A1 HETEROCYCLIC COMPOUNDS AS CBP SELECTIVE DEGRADERS AURIGENE ONCOLOGY LIMITED (IN) 2025-03-27 — — WO disclosed
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