Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428985 | 0.81 | TSHR (0.47) | GAAGRM5CYP1A2CYP3A4HTT | |
| SCHEMBL9256295 | 0.74 | GRM5 (0.48) | GAAGRM5CYP1A2CYP3A4HTT | |
| SCHEMBL1713222 | 0.73 | TSHR (0.57) | GAAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL4419406 | 0.72 | GRM5 (0.58) | GAAGRM5CYP1A2CYP3A4HTT | |
| SCHEMBL158497 | 0.71 | TSHR (0.55) | GAAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL11072823 | 0.71 | TSHR (0.55) | GAAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL1684895 | 0.70 | — | — | |
| SCHEMBL10985089 | 0.70 | ALDH1A1 (0.72) | GAAHTTL3MBTL1TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL27776511 | 0.70 | TSHR (0.53) | GAAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL12994041 | 0.70 | TSHR (0.53) | GAACYP1A2HTTTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449529-B1 | Protein Kinase C Inhibitors | LILLY CO ELI (US) | 2010-01-27 | — | — | EP | disclosed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0817627-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5672618-A | TREATING DIABETIC COMPLICATIONS | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| US-5668152-A | BIS/INDOLE/-SUBSTITUTED MALEIMIDES, ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5661173-A | ADMINISTERING AN ENZYME INHIBITOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5545636-A | TREATING DIABETES MELLITUS | ELI LILLY AND COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995017182-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1995-06-29 | — | — | WO | disclosed |