SCHEMBL31546426

SCHEMBL31546426

COc1ccc(-c2noc(N3CCN(c4cccc(Cl)c4)CC3)n2)cc1

nearest known ligand 0.78

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 13/20 0.78
▸ THRB P10828 2/20 0.78
▸ TP53 P04637 2/20 0.68
▸ GAA P10253 1/20 0.60
▸ LMNA P02545 4/20 0.58
▸ NPC1 O15118 1/20 0.58
▸ HTT P42858 1/20 0.58
▸ ALDH1A1 P00352 2/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ KMT2A Q03164 1/20 0.56
▸ TSHR P16473 1/20 0.53
▸ POLB P06746 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31546320 0.86 MAPT (0.75) MAPTTHRBTP53GAALMNA
SCHEMBL30584995 0.82 MEN1 (0.64) MAPTTHRBTP53GAALMNA
SCHEMBL31546357 0.81 MAPT (0.63) MAPTTHRBTP53GAALMNA
SCHEMBL28665714 0.81 MAPT (0.64) MAPTTHRBTP53GAALMNA
SCHEMBL28667773 0.80 MAPT (0.62) MAPTTHRBTP53GAALMNA
SCHEMBL30584791 0.78 MAPT (0.63) MAPTTP53LMNANPC1HTT
SCHEMBL31546316 0.77 MAPT (0.76) MAPTTHRBTP53LMNANPC1
SCHEMBL17100655 0.76 MAPT (0.66) MAPTTHRBTP53LMNANPC1
SCHEMBL25403067 0.76 MAPT (0.61) MAPTTHRBTP53LMNANPC1
SCHEMBL17100860 0.75 SIGMAR1 (0.57) MAPTTHRBTP53GAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12344600-B2 c-Myc mRNA translation modulators and uses thereof in the treatment of cancer ANIMA BIOTECH INC. (US) 2025-07-01 — — US disclosed
US-20250109128-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-04-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12344600-B2 c-Myc mRNA translation modulators and uses thereof in the treatment of cancer MYC, MYCBP, MYCBP2 MAPT 2999/4885THRB 2458/4885TP53 54/4885
US-20250109128-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 MAPT 2999/4885THRB 2458/4885TP53 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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