SCHEMBL31554537

SCHEMBL31554537

COCCOc1cc2ncc(F)c(Oc3ccc(N)cc3F)c2cc1OC

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AXL P30530 1/20 0.51
PDPK1 O15530 8/20 0.47
KIT P10721 1/20 0.47
FGFR1 P11362 4/20 0.44
FLT1 P17948 4/20 0.44
KDR P35968 3/20 0.44
EGFR P00533 2/20 0.43
FLT4 P35916 1/20 0.43
TRPA1 O75762 1/20 0.43
RET P07949 1/20 0.42
KIF5B P33176 1/20 0.42
GAK O14976 1/20 0.42
SRC P12931 1/20 0.42
FLT3 P36888 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31554419 0.91 KIT (0.54) AXLPDPK1KITKDREGFR
SCHEMBL31554548 0.85 AXL (0.45) AXLPDPK1KITKDREGFR
SCHEMBL14966993 0.84 AXL (0.69) AXLFGFR1FLT1KDRFLT3
SCHEMBL14771309 0.84 TRPA1 (0.64) AXLKITFGFR1FLT1KDR
SCHEMBL14771291 0.84 TRPA1 (0.64) AXLKITFGFR1FLT1KDR
SCHEMBL31554454 0.84 AXL (0.69) AXLFGFR1FLT1KDRFLT3
SCHEMBL31554431 0.83 S1PR4 (0.46) PDPK1FGFR1FLT1KDREGFR
SCHEMBL14771329 0.80 KDM1A (0.58) AXLKITFGFR1FLT1KDR
SCHEMBL5049628 0.80 AXL (0.64) AXLFGFR1FLT1KDRFLT3
SCHEMBL5054175 0.78 SRC (0.60) KITEGFRGAKSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096463-A1 PLK4 MODULATORS VIBLIOME THERAPEUTICS, LLC (US) 2025-05-08 WO disclosed