SCHEMBL31554548

SCHEMBL31554548

COc1cc2c(Oc3ccc(N)cc3F)c(F)cnc2cc1OCC(C)(C)O

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
AXL P30530 3/20 0.45
KIT P10721 2/20 0.45
TRPA1 O75762 1/20 0.42
KDR P35968 7/20 0.41
MET P08581 6/20 0.41
PDPK1 O15530 1/20 0.40
FGFR2 P21802 2/20 0.39
EGFR P00533 1/20 0.36
FLT3 P36888 2/20 0.36
PDGFRB P09619 1/20 0.36
PDGFRA P16234 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31554419 0.89 KIT (0.54) AXLKITTRPA1KDRPDPK1
SCHEMBL31554537 0.85 AXL (0.51) AXLKITTRPA1KDRPDPK1
SCHEMBL20032544 0.84 AXL (0.61) AXLKDRMETFGFR2FLT3
SCHEMBL25258803 0.79 AXL (0.49) AXLKDRMETFGFR2PDGFRB
SCHEMBL5054175 0.77 SRC (0.60) KITEGFR
SCHEMBL31554469 0.76 KIT (0.48) KITTRPA1KDRPDPK1EGFR
SCHEMBL31554394 0.76 ENPP1 (0.42) KDRFGFR2EGFR
SCHEMBL2226575 0.74 AAK1 (0.40) EGFR
SCHEMBL31554494 0.73 KIT (0.45) KITTRPA1KDRPDPK1EGFR
SCHEMBL1144185 0.73 GAA (0.60)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096463-A1 PLK4 MODULATORS VIBLIOME THERAPEUTICS, LLC (US) 2025-05-08 WO disclosed