SCHEMBL31554644

SCHEMBL31554644

CNC(=O)COc1cc2cc(Nc3nc(N4CCC(CNC(=O)OC(C)(C)C)CC4)ncc3Cl)ccc2n(C)c1=O

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.68
▸ MELK Q14680 1/20 0.68
▸ NCOR2 Q9Y618 7/20 0.67
▸ CHRM4 P08173 1/20 0.55
▸ BCL6B Q8N143 1/20 0.55
▸ ADRB3 P13945 1/20 0.41
▸ HTR1D P28221 1/20 0.41
▸ ADORA1 P30542 1/20 0.41
▸ OPRM1 P35372 1/20 0.41
▸ SLC6A3 Q01959 1/20 0.41
▸ TMEM97 Q5BJF2 1/20 0.41
▸ HRH3 Q9Y5N1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30706138 0.89 BCL6 (0.71) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267253 0.88 BCL6 (0.76) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20267589 0.88 BCL6 (0.62) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL31554638 0.88 BCL6 (0.75) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267189 0.88 BCL6 (0.75) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284725 0.87 BCL6 (0.79) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267872 0.87 BCL6 (0.64) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284547 0.87 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284724 0.87 BCL6 (0.83) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL22932328 0.87 BCL6 (0.78) BCL6MELKNCOR2CHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096706-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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