Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.63 |
| ▸ | HTR1D | P28221 | 4/20 | 0.63 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157871 | 0.80 | HTR1B (0.63) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL1873522 | 0.79 | HTR1B (0.48) | HTR1BHTR1DKMT2AMEN1HTR1A | |
| SCHEMBL12637222 | 0.79 | HTR1B (0.48) | HTR1BHTR1DKMT2AMEN1HTR1A | |
| SCHEMBL6527024 | 0.78 | HTR1B (1.00) | HTR1BHTR1DNR2E1HTR6KDR | |
| Hydrochloric Acid SCHEMBL7540641 | 0.77 | HTR1B (0.97) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL9334201 | 0.76 | HTR1B (0.69) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL15281767 | 0.74 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL14624295 | 0.74 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL24408397 | 0.73 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6KDR | |
| SCHEMBL6529421 | 0.73 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-1902026-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002181-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |