Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 6/20 | 0.63 |
| ▸ | HTR1D | P28221 | 4/20 | 0.61 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321122 | 0.81 | HTR1B (0.59) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL7410778 | 0.81 | HTR1F (0.55) | HTR1BHTR1DHTR6KMT2AHTR1A | |
| SCHEMBL3155776 | 0.80 | HTR1B (0.63) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL15281767 | 0.80 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL14624295 | 0.80 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| Hydrochloric Acid SCHEMBL7026693 | 0.80 | HTR1B (0.58) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL24408397 | 0.79 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL6529421 | 0.79 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL9336395 | 0.79 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL24408213 | 0.79 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-1902026-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002181-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |