Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31564823 | 1.00 | SIRT2 (0.47) | SIRT2SIRT1MAPK1LMNAMMP1 | |
| SCHEMBL31581616 | 0.85 | SIRT2 (0.52) | SIRT2SIRT1MAPK1MMP1MMP13 | |
| SCHEMBL31564563 | 0.85 | SIRT2 (0.52) | SIRT2SIRT1MAPK1MMP1MMP13 | |
| SCHEMBL31564712 | 0.85 | SIRT2 (0.52) | SIRT2SIRT1MAPK1LMNAMMP1 | |
| SCHEMBL18603269 | 0.84 | GRM2 (0.57) | SIRT2SIRT1MAPK1LMNAMMP1 | |
| SCHEMBL18622408 | 0.84 | GRM2 (0.57) | SIRT2SIRT1MAPK1LMNAMMP1 | |
| SCHEMBL31581772 | 0.82 | MMP1 (0.51) | SIRT2SIRT1MAPK1LMNAMMP1 | |
| SCHEMBL2191833 | 0.81 | ALDH1A1 (0.59) | MAPK1LMNAALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL6498337 | 0.77 | GRM2 (0.62) | SIRT2SIRT1MMP1MMP13GRM2 | |
| SCHEMBL6496941 | 0.77 | GRM2 (0.62) | SIRT2SIRT1MMP1MMP13GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096453-A1 | COMPOUNDS FOR THE TREATMENT OF KIDNEY DISEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-05-08 | — | — | WO | disclosed |